Why we need awareness #4

Below is a current, as of 5 minutes ago, list from clinicaltrials.gov. I searched “endometriosis” to find a listing of current open studies focusing on endometriosis. There is only one current, active trial examining the immunology of endometriosis. The majority of the studies below focus on medicinal and surgical treatment options and are likely sponsored by drug companies.

This is why we need awareness.

Rank Status Study
1 Recruiting Randomized Study of Gonadotropin-releasing-hormone Agonist (GnRH-a) or Expectant Management for Endometriosis 

Condition: Endometriosis
Intervention: Drug: gonadotropin-releasing-hormone agonist (GnRHa) – Goserelin
2 Recruiting Maintenance Therapy of Levonorgestrel-releasing Intrauterine System (LNG-IUS) to Prevent the Recurrence of Symptomatic Endometriosis After Conservative Surgery 

Condition: Endometriosis
Interventions: Device: LNG-IUS;   Drug: GnRH agonist (triptorelin)
3 Not yet recruiting Observational Program to Assess Routine Use of Add-back Therapy in Patients With Endometriosis in Russian Federation, Planned for 6-month Course of Lucrin Depot 

Condition: Genital Endometriosis
4 Recruiting ENDOMET – Novel Diagnostic Tools and Treatments for Endometriosis 

Condition: Endometriosis
5 Not yet recruiting The Immune Base of Endometriosis 

Condition: Endometriosis
6 Not yet recruiting Functional Outcomes of Surgical Management of Deep Endometriosis Infiltrating the Rectum 

Condition: Endometriosis of Rectum
Interventions: Procedure: Rectal/colorectal segmental resection;   Procedure: Rectal nodule excision
7 Recruiting A Safety & Efficacy Study of BGS649 in Women With Refractory Endometriosis 

Condition: Pelvic Pain Associated With Refractory Endometriosis
Interventions: Drug: BGS649;   Drug: Placebo
8 Recruiting Treatment of Endometriosis With Norethindrone Acetate ( NA) VS. Gonadotropin- Releasing Hormone (GnRH) Agonist (Lupron Depot 11.25 mg) 

Conditions: Endometriosis;   Dysmenorrhea;   Dyspareunia
Interventions: Drug: Norethindrone Acetate;   Drug: GnRH Agonist (Lupron Depot)
9 Recruiting Pelvic Pain in Women With Endometriosis 

Conditions: Endometriosis;   Pelvic Pain;   Healthy;   Tubal Ligation
10 Recruiting Medical Treatment of Endometriosis-Associated Pelvic Pain 

Conditions: Endometriosis;   Pelvic Pain
Interventions: Drug: Oral Contraceptive;   Drug: Depot-Leuprolide/Norethindrone
11 Recruiting Endometriosis: Immunomodulation 

Condition: Endometriosis
Intervention: Drug: Pioglitazone
12 Recruiting BGS649 Monotherapy in Moderate to Severe Endometriosis Patients 

Condition: Endometriosis
Intervention: Drug: BGS649
13 Recruiting The Effect of Hormonal Add-Back Therapy in Adolescents Treated With a GnRH Agonist for Endometriosis: A Randomized Trial 

Condition: Endometriosis
Interventions: Drug: Conjugated equine estrogens;   Drug: Placebo;   Drug: Norethindrone acetate
14 Not yet recruiting Continuous Postoperative Use of Low-Dose Combined Oral Contraceptivesfor for Endometriosis-Related Chronic Pelvic Pain 

Conditions: Endometriosis;   Chronic Pelvic Pain
Interventions: Drug: Continuous OC (clormadinone acetate plus ethinil-estradiol – Belara®, Grunenthal, Milan, Italy);   Drug: Cyclic OC (clormadinone acetate plus ethinil-estradiol)
15 Not yet recruiting Efficacy of Acupuncture on Chronic Pelvic Pain in Women With Endometriosis or Adenomyosis 

Conditions: Endometriosis;   Adenomyosis;   Pelvic Pain
Interventions: Procedure: acupuncture treatment;   Procedure: Sham acupunture
16 Recruiting Efficacy of Injectable Contraceptive and Oral Contraceptive Administered After Surgical Treatment of Endometriosis With Pain 

Condition: Endometriosis
Interventions: Drug: intramuscular depot medroxyprogesterone acetate;   Drug: ethinyl estradiol 30 micrograms, gestodene 75 micrograms
17 Recruiting Visanne Post-approval Observational Study (VIPOS) 

Condition: Endometriosis
18 Not yet recruiting Visanne Study to Assess Safety in Adolescents 

Condition: Endometriosis
Intervention: Drug: Dienogest (Visanne, BAY86-5258)
19 Recruiting Endometrial Biopsy as Diagnostic Method for Endometriosis and Endometrioma 

Conditions: Women in the Reproductive Age Group;   Undergoing Laparoscopy for Pelvic Pain and/or Infertility;   Not Currently Receiving Hormonal Treatment for at Least 3 Months Prior to Laparoscopy.
Intervention: Procedure: Endometrial biopsy
20 Recruiting Global Study of Women’s Health 

Conditions: Endometriosis;   Infertility;   Chronic Pelvic Pain;   Tubal Ligation
Rank Status Study
21 Recruiting Fertility Surgery, Prospective Analysis 

Condition: Endometriosis
22 Recruiting Exhaled Breath Biomarkers in Finding Ovarian Epithelial Cancer in Patients With Newly Diagnosed Ovarian Epithelial Cancer, Polycystic Ovarian Syndrome, or Endometriosis and in Healthy Participants 

Condition: Ovarian Cancer
Interventions: Other: Fourier transform ion cyclotron resonance mass spectrometry;   Other: chromatography;   Other: diagnostic laboratory biomarker analysis;   Other: questionnaire administration
23 Recruiting The In Vitro Fertilization – Lipiodol Uterine Bathing Effect Study 

Conditions: Endometriosis;   In Vitro Fertilization Implantation Failure
Interventions: Procedure: Lipiodol + IVF;   Procedure: IVF
24 Recruiting Evaluation of Endometrial Stromal Cell Apoptosis in Adenomyosis 

Condition: Endometriosis
25 Recruiting Decapeptyl SR With Livial Add Back Therapy in the Management of Chronic Cyclical Pelvic Pain in Pre Menopausal Women 

Condition: Endometriosis
Intervention: Drug: Decapeptyl SR 11.25mg
26 Not yet recruiting Postoperative Cyclic Oral Contraceptive Use for the Prevention of Endometrioma Recurrence 

Condition: Endometriosis
27 Recruiting Progestin Treatment for Endometrial Stromal Cells in Adenomyosis 

Condition: Endometriosis
28 Recruiting Data Collection of Patients Treated With the ColonRing™ for the Creation of Circular Compression Anastomosis 

Conditions: Diverticulum, Colon;   Colorectal Neoplasms;   Crohn Disease;   Colitis, Ulcerative;   Colostomy;   Ileostomy – Stoma;   Rectal Prolapse;   Intestinal Polyposis;   Lymphoma;   Endometriosis;   Intestinal Volvulus
Intervention: Device: ColonRing™
29 Recruiting ‘SPRING’-Study: “Subfertility Guidelines: Patient Related Implementation in the Netherlands Among Gynaecologists” 

Conditions: Male Infertility;   Female Infertility;   Ovarian Hyperstimulation Syndrome;   Premature Ovarian Failure;   Endometriosis
Interventions: Behavioral: patient education;   Behavioral: professional audit and feedback (guideline adherence);   Behavioral: professional education (communication/shared decision making);   Other: information tools
30 Recruiting Clinical Database and Biobank of Patients With Gynecologic Neoplasms 

Conditions: Cervical Cancer;   Ovarian Cancer;   Endometrial Cancer;   Choriocarcinoma;   Uterine Fibroids;   Endometriosis
31 Recruiting Short Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure 

Conditions: Cesarean Section; Complications;   Delayed Healing of Incision
Interventions: Procedure: Purse string closure;   Procedure: Continuously locked suturing
32 Recruiting Long Term Comparison of Two Different Techniques of Uterine Cesarean Incision Closure 

Conditions: Cesarean Section; Complications;   Placenta Previa;   Placenta Accreta
Interventions: Procedure: Purse string closure technique;   Procedure: Continuously locked closure technique
33 Not yet recruiting PTEN and IGFBP-3 Correlation in Ovarian Carcinoma Invasion 

Condition: Ovarian Cancer
Intervention: Procedure: immunohistochemical, methylation, gene transfection
34 Recruiting Differential Effects of Clomiphene Citrate in Women Undergoing Superovulation 

Condition: Mood
Interventions: Other: Placebo;   Drug: Clomiphene
35 Recruiting Impact of Hot Flashes on Sleep and Mood Disturbance 

Conditions: Menopause;   Depression;   Hot Flashes
Intervention: Drug: Leuprolide
36 Recruiting Study of Different Pain Scores in Single-Port Access (SPA) Laparoscopic Hysterectomy Versus Conventional Laparoscopic Hysterectomy 

Conditions: Uterine Myoma;   Uterine Adenomyosis
Interventions: Procedure: conventional laparoscopic hysterectomy;   Procedure: SPA laparoscopic hysterectomy
37 Recruiting Comparison of Hemostatic Matrix and Bipolar Coagulation in Surgical Treatment of Endometriomas 

Conditions: Ovarian Reserve;   Endometrioma
Interventions: Procedure: Bipolar electrocautery for ovarian hemostasis;   Procedure: hemostatic matrix (FloSeal)
38 Recruiting Single-port Access Laparoscopic-assisted Vaginal Hysterectomy 

Conditions: Uterine Myomas;   Adenomyosis
Intervention: Procedure: single-port LAVH
39 Recruiting Health-Related QoL Among Women Receiving Hysterectomy in NTUH 

Conditions: Leiomyoma;   Adenomyosis
Intervention: Behavioral: questionnaires

2 responses to “Why we need awareness #4

  1. Endochick,

    An estimated 89 MILLION women and girls worldwide have endometriosis (numbers vary widely depending on stat source… this is a conservative estimate)!

    “This makes endometriosis more common than AIDS and more common than cancer”, as per Ohio State University Medical Center. (Source: HERE).

    It is really pitiful that there is not more endometriosis research going on.


  2. Endochick,

    Study #24 excludes postmenopausal women. Yet adenomyosis patients are to be studied. Hmm. The last I knew the only definitive way to diagnose adenomyosis is to dissect the uterine tissue after the uterus has been REMOVED. How can they study adenomyosis patients AND exclude postmenopausal patients??? That makes no sense.


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